Chaperone Code Program
Full Symposia Schedules and Abstracts
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Thursday October 26, 2023
2-4pm: Registration Open
5pm: Welcome address by Mark Woodford
Dimitra Bourboulia introducing Keynote Lecture by
Johannes Buchner (Technical University of Munich, Germany)
“A code of conformational switching in Hsp90”
6pm: Dinner
Friday October 27, 2023
7:30-9:00am: Breakfast
9:00-11:00am: Session 1: Determinants of Hsp90 function.
Chair: Mark Woodford and Adrienne Edkins
9:00am Jill Johnson (University of Idaho, USA) "The conformational code of Hsp90 impacts Hsp90 activity"
9:15am Paul LaPointe (University of Alberta, Canada) "Ordered ATP hydrolysis is in the Hsp90 dimer is regulated by Aha1 and a conserved post-translational modification"
9:30am Andrea Rasola (University of Padova, Italy) "The chaperone code of TRAP1"
9:45am Q&A
9:55am Walid Houry (University of Toronto, Canada) "The Role of the Hsp90-R2TP Chaperone Complex in Ciliogenesis"
10:10am Chris Prodromou (University of Sussex, UK) "The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by which LA1011 may Improve the Prognosis of Alzheimer's Disease."
10:25am Dan Gewirth (University at Buffalo, USA) "The effects of site specific N-glycosylation on Grp94 structure and function"
10:40am Sarah Backe (State University of New York, USA) "The Hsp90 chaperone code regulates autophagy"
10:55am Q&A
11:05am Flash Talks: Pietro Poggio (University of Turin), Francesca Zuppini (University of Turin), Gianna Mochi (State University of New York)
11:25am Sponsor Presentation: Sino Biological
11:40am Sponsor Presentation: Nicoya
12:00-1:00pm: Lunch
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1:00-3:30pm: Session 2: Targeting Hsp90 Chaperone Complexes.
Chair: Mehdi Mollapour and Fortunate Mokoena
1:00pm Brian Blagg (Notre Dame University, USA) "The design and development of isoform-selective inhibitors of Hsp90"
1:15pm Giorgio Colombo (University of Pavia, Italy) "Deciphering the Hsp90 code with biocomputing"
1:30pm Byoung Heon Kang (Ulsan National Institute, South Korea) "Targeting TRAP1 in the tumor microenvironment: inhibitors and breast cancer treatment."
1:45pm Mark Woodford (State University of New York, USA) "The mitochondrial chaperone code drives pro-survival signaling in renal cell carcinoma"
2:00pm Q&A
2:10pm Ioannis Gelis (University of South Florida, USA) "Co-chaperone targeted Hsp90 phosphorylation during kinase processing"
2:25pm Maria Theodoraki (Arcadia University) "Investigating the effects of DAP-19, a novel Hsp90β inhibitor, on breast cancer cell lines"
2:40pm Rebecca Sager (State University of New York, USA) "Regulation of protein phosphatase 5 (PP5) activity and substrate release by SUMOylation"
2:55pm Q&A
3:05pm Flash Talks: Katie Meluni (State University of New York), So-yeon Kim (UNIST), Nam Gu Yoon (UNIST), Vamsi Krishna Kommalapati (Augusta University)
3:30-3:45pm: Break
3:45-5:15pm: Session 3: Drivers of the Cell Stress Response.
Chair: Gary Jones and Andrew Truman
3:45pm Lea Sistonen (Abo Akademi University, Finland), "Searching for HSF Interactomes"
4:00pm Aimee Kao (UCSF, USA) "TSC1 as the molecular link between neurodevelopmental and neurodegenerative tauopathies"
4:15pm Natasha Zachara (Johns Hopkins, USA), “The intersection between O-GlcNAc, AMPK, and Cytoprotection”
4:30pm Richard Carpenter (Indiana University, USA) “Emerging roles for HSF1 in Breast Cancer”
4:45pm Milad Alasady (Northwestern University, USA), "A JMJD6-HSF1-HSP feed forward circuit promotes cell adaptation to proteotoxic stress."
5:00pm Q&A
5:10pm Flash Talks: Jenny Pessa (Abo Akademi University), Sarah Rolli (Marquette University), Smriti Sangwan (UCSF)
6:00pm: Dinner
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Saturday October 28, 2023
7:30-8:30am: Breakfast
8:30am Special Presentation: Ilse Ariadna Valtierra Gutierrez (Senior Editor, Nature Communications)
8:45am-11:00am: Session 4: The Hsp70 Chaperone Code.
Chair: Dimitra Bourboulia and Seema Mattoo
8:45am Lila Gierasch (University of Massachusetts, Amherst, USA) "The Hsp70 Substrate-Binding Code"
9:00am Len Neckers (NCI, USA) "Metabolism-Dependent PTMs –Lactylation of Specific Proteostasis Network Components"
9:15am Andrew Truman (UNC Charlotte, USA) "Systematic analysis of Hsp70 phosphorylation using the chaperone code collection"
9:30am Seema Mattoo (Purdue University, USA) "Manipulating AMPylation"
9:45am Matthias Truttmann (University of Michigan, USA) "New insight into Hsp70 regulation by protein AMPylation"
10:00am Amie Jo McClellan (Bennington College) "Exploring VHL as a model misfolded substrate for lysine-independent quality control"
10:15am Q&A
10:30am Flash Talks: Valeria Uvarova (UNC Charlotte), Siddhi Omkar (UNC Charlotte), Leon Tang Jia Wei (National University of Singapore), Asif Elahi (Augusta University), Duhita Mirikar (UNC Charlotte)
11:00am Special presentation on Cell Stress & Chaperones Journal
11:30am Winner of Best Flash Talks Announcement